Systems Chemical Biology of Infection and Resistance Laboratory

The SCBIR lab is based the Francis Crick Institute in London. We use large-scale genetics and chemical biology to study how pathogenic bacteria infect and evolve resistance to antibiotics.

Ultimately, we aim to enable antimicrobial therapies which exploit key weaknesses in the ability of pathogenic bacteria to infect and evolve resistance to antibiotics.

Our work focuses on these areas (click the links for more information):

• Accelerating discovery of new small molecules with new targets
  • Rapid target annotation
  • Optimising chemical library design
• Defining targets for bacterial survival and infection

Find out more about our research here!